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KMID : 1240020160200030182
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International Neurourology Journal
2016 Volume.20 No. 3 p.182 ~ p.187
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Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells
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Choi Bo-Hwa
Lee Da-Hyun
Kim Jin
Kang Ju-Hee
Park Chang-Shin
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Abstract
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Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5´-AMP-activated protein kinase (AMPK) activators such as 5´-aminoimidazole-4-carboxamide ribonucleotide (AICAR) or the hypoglycemic agent metformin. We found that AICAR or metformin acts as a regulator of LPS/NF-κB-or hypoxia/NF-κB-mediated cyclooxygenase induction by an AMPK-dependent mechanism with interactions between p65-NF-κB phosphorylation and acetylation, including in a human bladder cancer cell line (T24). In summary, we highlighted the regulatory interactions of AMPK activity on NF-κB induction, particularly in posttranslational phosphorylation and acetylation of NF-κB under inflammatory conditions or hypoxia environment.
Keywords: NF-kappa B; AMP-Activated P
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KEYWORD
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NF-kappa B, AMP-Activated Protein Kinases, Lipopolysaccharides, Hypoxia
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